Deriva Aqueous gel adapalene 0.1% – 15g
Adapalene is a retinoid-like compound for the treatment of acne vulgaris. It is a naphthoic derivative with a methoxyphenyl adamantyl side chain. Biochemical and pharmacological profile studies have demonstrated that adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes all of which represent important features in the pathology of acne vulgaris.
Adapalene binds to specific retinoic acid nuclear receptors but does not bind to the cytosolic receptor protein. It has been suggested that topical adapalene may normalize the differentiation of follicular epithelial cells resulting in decreased microcomedone formation.
Analysis of cryosections, radioactive tracing and fluorescence studies in excised human skin have shown that adapalene gel penetrates into the epidermis and dermis (especially the pilosebaceous units).